Genetic Effects of Blood Pressure Quantitative Trait Loci on Hypertension-Related Organ Damage: Evaluation Using Multiple Congenic Strains
نویسندگان
چکیده
منابع مشابه
Two linked blood pressure quantitative trait loci on chromosome 10 defined by dahl rat congenic strains.
Aquantitative trait locus (QTL) for blood pressure was previously detected on rat chromosome 10 (RNO10) by linkage analysis and confirmed by the construction of congenic strains that encompass large regions of RNO10. In the present study, the rat RNO10 blood pressure QTL was dissected by the further construction of congenic substrains. The original congenic region was shown to contain 2 blood p...
متن کاملComprehensive congenic coverage revealing multiple blood pressure quantitative trait loci on Dahl rat chromosome 10.
Chromosome mapping based on congenic strains can restrict quantitative trait loci (QTLs) for blood pressure (BP) into small intervals that are otherwise indistinguishable in linkage analysis. Also, congenic strains can be created to test a candidate gene to be a BP QTL. Taking full advantage of these features, we produced 10 congenic strains by replacing various segments of chromosome (Chr) 10 ...
متن کاملIdentifying candidate genes for blood pressure quantitative trait loci using differential gene expression and a panel of congenic strains.
The most difficult step in dissecting the molecular basis of a quantitative trait is proceeding from chromosomal locations associated with this trait (i.e., quantitative trait locus, QTL) to determining what gene(s) in the QTL region is causative. Using standard positional cloning methodology to identify candidate genes for a particular QTL has three drawbacks: 1) it is labor intensive; 2) defi...
متن کاملSuccessful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains.
Linkage analyses in experimental crosses of hypertensive and normotensive rats have strongly suggested the presence of a quantitative trait locus (QTL) influencing blood pressure on rat chromosome 1, at or near the Sa gene. To confirm the presence of such a locus and move toward identification of the causative gene, we have developed, through targeted breeding over 10 generations using an Sa ge...
متن کاملMultiple trait analysis of genetic mapping for quantitative trait loci.
We present in this paper models and statistical methods for performing multiple trait analysis on mapping quantitative trait loci (QTL) based on the composite interval mapping method. By taking into account the correlated structure of multiple traits, this joint analysis has several advantages, compared with separate analyses, for mapping QTL, including the expected improvement on the statistic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hypertension Research
سال: 2008
ISSN: 0916-9636,1348-4214
DOI: 10.1291/hypres.31.1773